Your DNA may protect you from C-19’s worst symptoms…

Maybe 23and Me has a socially redeeming value, after all .
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According to Bloomberg

Some people experience Covid-19 as nothing more than a mild cold, and others exhibit no symptoms at all.

Then there are the thousands who sicken and, often, die.

No one knows why there are such huge discrepancies in symptoms and outcomes.

One theory: It is locked deep in our genetic makeup.

So, a global consortium of scientists is working to unlock the mystery of the disease’s dramatically varying symptoms.

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The theory of the case.

Some people’s genes may simply make them more vulnerable to severe illness, while others’ genetics may confer resistance.

In technical terms, this is called “Host Genetics.”

It is generally accepted that our genes do play a role in how we respond to viral infections.

Certain genetic variants, especially in genes that influence the immune system, seem to predispose people to a host of infectious diseases.

There are some early indications of this with the novel Covid-19 coronavirus.

The receptor it uses to penetrate host cells, called ACE2, can be present in varying numbers in different people based on their genetics and on environmental factors, such as what medicines they take.

“But beyond theory, there’s very little data so far.”

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The attack plan

Pharmaceutical companies and scientists are working the case.

For example The Host Genetics Initiative is a collaboration of hundreds of scientists at dozens of institutions conducting more than 100 studies that aim to examine the genetics of people infected by coronaviruses.

So is is DNA collector 23andMe.

23andMe is “putting its vast trove of genetic data to use hunting for clues about how the virus works.”

The company plans to survey customers who contracted Covid-19 and look for commonalities among those who experienced a severe response.

They hope to identify specific regions of the genome that may hold the key that unlocks the puzzle.

The ultimate goals: Identify and protect those more at risk … and “inform” treatment and drug development.

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My view: I think this is a vey exciting research track

As a “vulnerable” who hasn’t been infected (yet), I’d love to know if my genes predispose me to be resistant from C-19 effects … or prone towards severe symptoms.

If the former (likely resistant), I’d be inclined to take some modicum of socialization risk

If the latter (prone to severe symptoms), then for sure, I’d continue to hole-up until a vaccine (or very effective therapy) becomes available.

It would be nice to know.

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