Part 4: “Unexpected things happen when you start fiddling with the innards of living cells.”

So, what are the “unexpected things” that might happen?
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In prior posts, I opined that:

  • The above headlined  warning from the book Code Breaker resonated with me
  • My most trusted med-science sources told me that the warning was applicable to covid vaccines.
  • Unlike most traditional vaccines, all of the current emergency-approved covid vaccines “fiddle with cells” in one way or another.
  • The mRNA vaccines (Pfizer & Moderna) are generally presumed to be safe — both short- and long-run since their fragile RNA strands “fiddle” with cells, but do not penetrate cells’ DNA-storing nuclei … and, are “eventually destroyed by the cell, leaving no permanent trace.”
  • The CDC assures that — for the J&J viral vector DNA vaccine — “genetic material in the vaccines cannot affect or interact with our DNA in any way” … because “the (vaccine’s) material never enters the nucleus of the cell, which is where our DNA is kept.”
  • But, a senior NY Times science reporter investigated and concluded that when injected, “the vaccine’s adenovirus component … pushes its DNA into the nucleus, the chamber where the cell’s DNA is stored.
  • That’s not a trivial difference in opinion.

We left off in Part 3 with a question: If the NYT is right, what are the possible implications?

This is where my anxieties kick in.

Here’s some science that I dutifully followed …

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A trusted med-science source linked me to a technical article on Adenoviruses & Pathogenesis.

The article had a statement re: pathogenesis (i.e. the development of diseases) that caught my eye:

Some adenovirus types are oncogenic in newborn rodents and can transform cells.

Human oncogenesis has not been found but may nevertheless occur (e.g., by a “hit-and-run” mechanism).

Translation: A possible link between adenoviruses and cancer.

More specifically…

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Drilling down on “human oncogenesis(i.e., cancer-causing)  I found this information re: DNA Oncoviruses:

Three DNA oncoviruses have been studied extensively: Adenoviruses, Simian virus 40 (SV40), Human papillomavirus-16 (HPV-16).


All three of these DNA oncoviruses are able to integrate their DNA into the host cell, and use this to transcribe it and transform cells by bypassing the G1/S checkpoint of the cell cycle.

Which led me to Integration of Viral DNA

DNA oncoviruses transform infected cells by integrating their DNA into the host cell’s genome.


The DNA is believed to be inserted during transcription or replication, when the two annealed strands are separated.


This event is relatively rare and generally unpredictable; there seems to be no deterministic predictor of the site of integration.


After integration, the host’s cell cycle loses regulation from Rb and p53, and the cell begins cloning to form a tumor.

Which led me to a  “red flag” article: Engineering DNA vaccines against infectious diseases

6.2. Insertional mutagenesis of viral delivery methods


DNA vaccines may cause indel mutations, the risks of which depend on the mechanism of delivery.


The administration of a DNA vaccine exposes the patient to foreign DNA or its fragments that could be inserted into the host’s chromosomal DNA.


In the case of incorporation into an exon, an insertional mutation or a frameshift mutation occurs.


Such mutations can cause a gene to malfunction or inactivate (i.e., a tumor suppressor gene).

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Bottom line: There appears to be “science” that — when followed — suggests a possible “rare and unpredictable” link between viral vector adenoviruses and cancer.

That said, the CDC (and the sometimes right Dr. Fauci) categorically claim that the “genetic material in the vaccines cannot affect or interact with our DNA in any way.”

That assertion, while untested over time, may be true.

But, as they say in Code Breaker:

“Unexpected things happen when you start fiddling with the innards of living cells.”

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My advice: caveat emptor, keeping in mind my usual disclaimer that:…

I’m not a medical professional or scientist — just a curious, self-interested guy.  So, don’t take anything that I say or write as medical advice. Get that from your doctor!

One Response to “Part 4: “Unexpected things happen when you start fiddling with the innards of living cells.””

  1. Dave Says:

    Thanks for boiling down this difficult topic to make it easier to digest, Professor Homa. Enjoy reading your posts!

    |Some adenovirus types are oncogenic in newborn rodents and can |transform cells.

    |Human oncogenesis has not been found but may nevertheless |occur (e.g., by a “hit-and-run” mechanism).

    Searched for the above in the linked paper but couldn’t find it.

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